evaluation of antinociceptive effect of pregabalin in mice and its combination with tramadol using tail flick test
نویسندگان
چکیده
the development of combination therapy is a coherent approach in severe pain treatment. the present study investigated the antinociceptive effect of pregabalin alone and in combination with tramadol in acute pain modeling. therefore, three groups of male mice received either pregabalin (1 to 400 mg/kg), tramadol (10 to 80 mg/kg) or their combination intraperitoneally. then latency time, maximum possible effect (%mpe) and area under curve (auc) were calculated in tail flick test. the antinociceptive indexes were significantly increasedin10, 100 and 200 mg/kg ofpregabalin while tramadol showed dose-dependentantinociception (effective dose 50% was 54 to 79 mg/kg). the antinociceptive effect of 100 mg/kg of pregabalin (%mpe = 35±4%) was similar to that of 50 mg/kg of tramadol. the combination of non-analgesic doses (10 mg/kg) of tramadol and pregabalin did not increase %mpe and auc, but the co-administration of 30 mg/kg of tramadol with pregabalin (10 mg/kg) increased all antinociceptive indexes significantly compared to the controls and with each drug alone. in conclusion, pregabalin showed a comparable antinociceptive effect to tramadol. the increase in analgesic effect was observed after the combination of low analgesic doses of tramadol with pregabalin, while the combination of non-analgesic doses of each drug reversed the interaction to antagonism. therefore to increase the analgesic effect in pain management, more attention should be paid to respecting right proportion of drug combination. further studies that specify the mechanism(s) and statement of interaction are needed to expand these findings to clinical applications.
منابع مشابه
Evaluation of Antinociceptive Effect of Pregabalin in Mice and its Combination with Tramadol using Tail Flick Test
The development of combination therapy is a coherent approach in severe pain treatment. The present study investigated the antinociceptive effect of pregabalin alone and in combination with tramadol in acute pain modeling. Therefore, three groups of male mice received either pregabalin (1 to 400 mg/Kg), tramadol (10 to 80 mg/Kg) or their combination intraperitoneally. Then latency time, maximum...
متن کاملEvaluation of Antinociceptive Effect of Pregabalin in Mice and its Combination with Tramadol using Tail Flick Test
The development of combination therapy is a coherent approach in severe pain treatment. The present study investigated the antinociceptive effect of pregabalin alone and in combination with tramadol in acute pain modeling. Therefore, three groups of male mice received either pregabalin (1 to 400 mg/Kg), tramadol (10 to 80 mg/Kg) or their combination intraperitoneally. Then latency time, maximum...
متن کاملEvaluation of Antinociceptive Effect of Pregabalin in Mice and its Combination with Tramadol using Tail Flick Test
The development of combination therapy is a coherent approach in severe pain treatment. The present study investigated the antinociceptive effect of pregabalin alone and in combination with tramadol in acute pain modeling. Therefore, three groups of male mice received either pregabalin (1 to 400 mg/Kg), tramadol (10 to 80 mg/Kg) or their combination intraperitoneally. Then latency time, maximum...
متن کاملevaluation of antinociceptive effect of pregabalin in mice and its combination with tramadol using tail-flick test
متن کامل
Evaluation of the analgesic effect of Mellissa officinalis extract by tail-flick test in mice
Bibliographical studies have been done on plants that are used as analgesics in traditional medicine, and Mellissa officinalis or Lemon Balm (LB) that there are some evidence indicating for its application as analgesics or its probable analgesic effect was selected for evaluation of analgesic effect by tail-flick test in mice. After scientific identification, the leaves and flowered branches ...
متن کاملThe Role of NMDARs Ligands on Antinociceptive Effects of Pregabalin in the Tail Flick Test
BACKGROUND Pregabalin as a new anticonvulsant has been used in different pain treatments. OBJECTIVES The aim of this study was to investigate the role of N-methyl-D-aspartate (NMDA) ligands in antinociceptive effect of pregabalin in mice using tail flick. MATERIALS AND METHODS NMDA (15 and 30 mg/kg) as an agonist or MK801 (0.02 and 0.05 mg/kg) as an antagonist were injected intraperitoneall...
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عنوان ژورنال:
iranian journal of pharmaceutical researchجلد ۱۲، شماره ۳، صفحات ۴۸۳-۴۹۳
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